Abstract: The present invention relates to the field of nanopowder preparation technology, specifically, laser evaporation multi-chamber nanopowder preparation device. At least two main chamber powder generation units are installed; each main chamber powder generation unit is connected to the vacuum main channel through the respective vacuum branch pipeline, and the vacuum main channel is connected to the vacuum pump group system; each main chamber powder generation unit is connected to the exhaust main channel through the respective exhaust branch pipeline, and each main chamber powder generation unit is connected to the intake main channel through the respective intake branch pipeline; each main chamber powder generation The main chamber powder generation unit is connected to the laser generator and control system through the respective laser control signal line and the respective feeding control signal line. The present invention avoids mutual contamination in the powder preparation process and improves the purity of the powder; realizes the simultaneous preparation of a variety of powders with different compositions; realizes continuous production; and greatly improves production efficiency and reduces costs.