Abstract: The present invention relates to the field of nanopowder preparation technology, specifically, a multi-chamber nanopowder preparation device for evaporation from a thermal arc and laser composite heat source. At least two main chamber powder generation units are installed; each main chamber powder generation unit is connected to a vacuum main through a respective vacuum branch pipe, and the vacuum main is connected to a vacuum pump group system; each main chamber powder generation unit is connected to an exhaust main through a respective exhaust branch pipe, and each main chamber powder generation unit is connected to an intake main through a respective intake branch pipe; each main chamber powder generation The main chamber powder generation unit is connected to the arc power and control system through the respective hot arc control signal line, laser signal line and respective feed control signal line. The present invention avoids mutual pollution in the process of powder preparation and improves the purity of the powder; realizes the simultaneous preparation of a variety of powders with different compositions; realizes continuous production; greatly improves production efficiency and reduces costs.